Common Knee Injections for Osteoarthritis

Arthritis affects almost 60 million people in the United States, with the most common type being osteoarthritis. Osteoarthritis (OA), commonly known as wear-and-tear arthritis, is a degenerative disease that results in the loss of cartilage within a joint. Knee osteoarthritis occurs when the cartilage in your knee joint breaks down over time, resulting in little to no cushion within the joint. Symptoms of knee osteoarthritis can include: 

  • Pain 
  • Swelling 
  • Stiffness 
  • Weakness or Instability 

There are many options when it comes to combating symptoms of knee OA. Among these options, knee injections have gained significant attention for their effectiveness in providing relief. In this blog post, we will explore three different knee injection options: corticosteroid injections, viscosupplementation, and Platelet Rich Plasma (PRP) Therapy.  

Corticosteroid Injections

Corticosteroid injections are one of the most frequently used treatments for knee osteoarthritis.  These injections contain powerful anti-inflammatory medications known as corticosteroids, which help reduce pain and inflammation in the affected joint. The procedure involves injecting the medication directly into the knee joint guided by ultrasound. 

Benefits of Corticosteroids:

  • Fast Relief: Corticosteroid injections provide rapid pain relief, allowing individuals to regain their mobility and engage in daily activities with greater ease.
  • Anti-inflammatory Properties: Corticosteroids help reduce inflammation in the knee joint, addressing one of the primary causes of pain in osteoarthritis. 
  • Accessibility: Corticosteroid injections are widely available, and the procedure can be performed in an outpatient setting, making it convenient for patients.
  • Cost-Effectiveness: Compared to some other treatment options, corticosteroid injections are relatively affordable.

Limitations and Considerations:

  • Temporary Relief: The effects of corticosteroid injections are typically temporary, ranging from a few weeks to several months. Repeat injections may be required for long-term management.
  •  Not Suitable for Everyone: Corticosteroid injections may not be suitable for individuals with certain medical conditions or those who are taking specific medications. Consultation with a healthcare professional is essential before opting for this treatment.


Viscosupplementation involves injecting hyaluronic acid (HA) into the knee joint. HA is a naturally occurring substance that provides lubrication and shock absorption in healthy joints. In osteoarthritis, the HA concentration decreases, leading to joint stiffness and pain. Viscosupplementation aims to restore the joint’s natural balance and reduce pain.

Benefits of Viscosupplementation:

  1.  Improved Joint Lubrication: The injected HA acts as a lubricant, reducing friction between the bones and improving joint mobility.
  2. Long-Lasting Effects: Viscosupplementation injections can provide pain relief for several months, potentially delaying the need for more invasive treatments such as surgery.
  3. Minimal Side Effects: Viscosupplementation is generally well-tolerated, with few side effects reported.

Limitations and Considerations:

  • Variable Response: The effectiveness of viscosupplementation can vary from person to person. Some individuals experience significant pain relief, while others may not respond as well to the treatment.
  • Treatment Duration: Viscosupplementation typically involves a series of injections, usually given weekly or monthly, depending on the specific product used. Patients need to commit to the entire treatment course for optimal results.
  • Allergic Reactions: Although rare, some individuals may experience allergic reactions to the injected hyaluronic acid. Consultation with a healthcare professional is crucial to evaluate the appropriateness of this treatment.

Platelet-Rich Plasma (PRP) Injections

PRP injections involve using the patient’s own blood, which is processed to concentrate the platelets. These platelets contain growth factors that can stimulate tissue repair and regeneration. When injected into the knee joint, PRP aims to promote healing and reduce pain associated with osteoarthritis.

Benefits of PRP Injections:

  1. Natural Healing: PRP utilizes the body’s own healing mechanisms, harnessing the regenerative potential of platelets to repair damaged tissue.
  2. Potentially Slows Disease Progression: PRP injections may not only alleviate symptoms but also have the potential to slow the progression of osteoarthritis.
  3. Minimal Side Effects: Since PRP utilizes the patient’s blood, the risk of adverse reactions or complications is minimal.

Limitations and Considerations:

  1. Limited Scientific Evidence: While many patients report positive outcomes with PRP injections, the scientific evidence supporting its effectiveness in treating osteoarthritis is still evolving. Further research is needed to establish its long-term benefits conclusively.
  2. Multiple Injections: PRP treatments often involve multiple injections spaced over several weeks or months to achieve optimal results. Patience and commitment are essential for the treatment’s success.
  3. Individual Response: Similar to other treatments, individual responses to PRP injections can vary. Some individuals experience significant pain relief, while others may not respond as favorably.

Knee injections offer a non-surgical approach to manage the symptoms of osteoarthritis, providing pain relief and improving joint function. Corticosteroid injections, viscosupplementation, and PRP injections each have their advantages and limitations. It is important to consult with a healthcare professional to determine the most appropriate treatment option based on individual circumstances and preferences.

While knee injections can offer substantial relief, they are not a cure for osteoarthritis. These injections work best when combined with a comprehensive treatment plan that may include physical therapy, lifestyle modifications, and other interventions. By exploring these treatment options and working closely with healthcare professionals, individuals with knee osteoarthritis can find effective strategies to improve their quality of life and maintain an active lifestyle.

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